The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

In his previous book, La philosophie et les experiences naturelles, A. De Waelhens claims that great philosophers in the past have not only been in dialogue with their predecessors but also that each great philosopher benefited from a confrontation with a non-philosophical experience. This previous book forms the theoretical justification for the present one. Here the author studies the problem of psychosis, with the hope and the intention of contributing to the further development of philosophy. Insofar as philosophy is fascinated (...) with the obligation "Learn to know yourself" or the search for an answer for the question "Who am I," insofar so claims the author, contemporary philosophy cannot afford to bypass psychoanalysis. The book has six chapters and a conclusion, but could easily be divided in three parts. The first part is a survey of the general approach to psychosis and schizophrenia by a selected group of European psychiatrists. The author indicates the crucial shortcomings of each approach and shows how there is among them a gradual turning away from a physiological interpretation of schizophrenia and psychosis towards a psychological one. In Part II, the author uses mainly the theory of Lacan and his disciples to present a coherent theory of psychosis. The crucial concepts are 1) the Oedipus-complex, 2) the mirror stage, 3) the foreclosure of a reference to the father. The Oedipus-complex is well known from Freud’s works although it receives here a more structural interpretation. The mirror stage refers to the events around 6-8 months when the child has to appropriate himself as a unified body, not just a collection of partial elements. This task can be noticed easily when one observes the attitude of the child towards the mirror. Hence the name. In order to perform this task successfully the child needs the support of the mother. The function of the mother is still more important for the third problem: a reference to the father. A healthy development of the child requires that the mother is capable of recognizing and of acknowledging the part played by the father in the creation of the child. This is done in our culture by giving the child the name of the father. Mothers of psychotics often are emotionally unable to tolerate that. They want to situate their child exclusively in relation to themselves: they foreclose any reference to the father. Psychosis is therefore related to the foreclosure of the name-of-the-father. These three crucial concepts allow the author to explain the crucial symptoms of schizophrenia, and to compare it with paranoia and paraphrenia. The third part of the book is a philosophical discussion of the problem of psychosis. The author offers the continental philosophical tradition as a better intellectual framework to study psychosis than the physical framework that Freud used in his Project for a Scientific Psychology and that he never completely abandoned. In the conclusion A. De Waelhens summarizes the direct philosophical consequences of the study of psychosis, the most fascinating being that one has to recognize the priority of language in the constitution of the subject, and that there is a meaningful relation between the way I relate to myself, the things and other people. Two improvements could be made in the book. The first is pedagogical: i.e., a critical bibliography of the crucial works of Lacan and his school and of the phenomenological tradition would have been very helpful for any reader not familiar with one of the two streams of thought. A second improvement would be the inclusion in Chapter One of a discussion of the development which has taken place in the U.S.A. in the explanation of schizophrenia. It is parallel with the development in Europe. A useful reference is E. G. Mishler and N. E. Walker: "Family Interaction Processes and Schizophrenia: A Review of Current Theories," in International Journal of Psychiatry, July 1966, Vol. 2, Number 4. Although the book is difficult, it is very insightful and provocative and it certainly merits translation.—W. V. E. (shrink)

In terms of validity in Kripke frames, a modal formula expresses a universal monadic second-order condition. Those modal formulae which are equivalent to first-order conditions are called elementary. Modal formulae which have a certain persistence property which implies their validity in all canonical frames of modal logics axiomatized with them, and therefore their completeness, are called canonical. This is a survey of a recent and ongoing study of the class of elementary and canonical modal formulae. We summarize main ideas and (...) results, and outline further research perspectives. (shrink)